Crosstalk from Insulin signaling pathway to Wnt signaling pathway

List of curated literature with evidence for crosstalk from Insulin signaling pathway to Wnt signaling pathway

  • New insights into the role of cAMP in the production and function of the incretin hormone glucagon-like peptide-1 (GLP-1).

    • PubMed ID : 19772917
    • Molecule in Insulin signaling pathway: PRKACA
    • Species : Homo sapiens
    • Transcription : no

    • Molecule in Wnt signaling pathway: CTNNB1
    • Tissue : pancreas
    • Regulation type : Activating
    • Sentence from paper : GLP-1 also stimulated β-cat phosphorylation at Ser675, and this is likely mediated by PKA activation

  • Modulation of β-catenin signaling by glucagon receptor activation.

    • PubMed ID : 22438981
    • Molecule in Insulin signaling pathway: Gcgr
    • Species : Mus musculus
    • Transcription : no
    • Sentence from paper : So activation of GCGR upon ligand binding can directly cross-talk to Lrp5/6 to transmit downstream β-catenin signaling whereas phosphorylation and activation of Lrp5/6 on the other hand can communicate back to GCGR to boost GCGR mediated cAMP/PKA pathway

  • Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling.

    • PubMed ID : 24233023
    • Molecule in Insulin signaling pathway: IRS2
    • Species : Homo sapiens
    • Transcription : no

    • Molecule in Wnt signaling pathway: CTNNB1
    • Tissue : intestine
    • Regulation type : Inhibiting
    • Sentence from paper : In addition, insulin receptor substrate 2 gene depletion blocked metformin-enhanced B-catenin translocation.

  • Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation.

    • PubMed ID : 24645679
    • Molecule in Insulin signaling pathway: Igf1
    • Species : Rattus norvegicus
    • Transcription : no
    • Sentence from paper : This effect takes place in a Wnt-independent manner because TSH and IGF-1, through the activation of protein kinase A and protein kinase B/Akt, phosphorylate β-catenin at S552 and S675, which results in β-catenin release from E-cadherin at the adherens junctions.

Molecules mediating the crosstalk
Molecule in Insulin signaling pathwayMolecule in Wnt signaling pathwayTissueSpeciesPubMed Identifier
PRKACACTNNB1pancreasHomo sapiens19772917
GcgrLrp5/Lrp6hepatocyteMus musculus22438981
IRS2CTNNB1intestineHomo sapiens24233023
Igf1Ctnnb1PCCL-3 cell, FRTL-5 cellRattus norvegicus24645679

Note: "Unknown" indicates that the molecule has not been identified.

Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.

Attribute NameDescription
Pathway A

The name of the upstream (first) pathway in a pair of crosstalking pathways.

Pathway B

The name of the downstream (second) pathway in a pair of crosstalking pathways.

Pubmed Query

The string used as a structured query in PubMed that returned the recorded PMID as a result.

PMID

The PubMed identifier for the reported publication.
We recorded "NO_RESULTS_FOR_PUBMED_QUERY" as a dummy PMID when the PubMed query returned no results.

Crosstalk

yes, if Pathway A elicits a downstream transcriptional response in Pathway B.
no, otherwise.

Transcriptional

yes, if the crosstalk is transcriptional.
no, otherwise.

Regulation type

The downstream effect on Pathway B. This attribute can take one of the following two values:

  • Activating: Stimulation of Pathway A up-regulates a gene or activates a protein that is representative of Pathway B.
  • Inhibiting: Stimulation of Pathway A down-regulates a gene or inhibits a protein that is representative of Pathway B.
Molecule A*

The molecule in Pathway A responsible for mediating crosstalk to Pathway B.

Molecule A Identifier

Unique identifier for Molecule A in the namespace recorded in "Molecule A Source", e.g., the UniProt ID of a protein.

Molecule A Source

The name of database that the value in "Molecule A Identifier" comes from, e.g., "UniProt" if the molecule is a protein.

Molecule B*

The molecule in Pathway B responsible for mediating crosstalk from Pathway A.

Molecule B Identifier

Unique identifier for Molecule B in the namespace recorded in "Molecule B Source", e.g., the UniProt ID of a protein.

Molecule B Source

The name of database that the value in "Molecule B Identifier" comes from, e.g., "UniProt" if the molecule is a protein.

Species

The name of the species in which the crosstalk was observed.

Tissue

The name of the tissue or cell line in which the crosstalk was observed.

BTO ID

The BRENDA Tissue Ontology (BTO) Identifier of the tissue or cell line in which the crosstalk was observed.

Condition

Notes on the experimental condition in the publication.

Sentence from paper

The sentence in the publication supporting the crosstalk. We record a sentence only if it states that Pathway A increases or decreases Pathway B signaling. The sentence may also include information about the proteins or genes responsible for mediating the crosstalk.

Misleading evidence for crosstalk

A sentence in the paper that appears to support evidence for crosstalk when the study does not conclude there is crosstalk.

Additional notes

A curator's notes that may provide rationale for the values recorded for the attributes.

*This attribute may represent either an individual molecule or several molecules. We use the following syntax for this attribute.

  • colon (:): The molecules participate in the complex, e.g., SMAD3:SMAD4 in the case of crosstalk from the TGF-beta signaling pathway to the Hippo signaling pathway (the complex consisting of SMAD3 and SMAD4 mediates this crosstalk).
  • slash (/): Either of the molecules can mediate the crosstalk, e.g., YAP1/WWTR1 for the same pair of pathways (YAP1 or WWTR1 can mediate the crosstalk).
  • comma (,): All the molecules are required for the crosstalk but they do not form a complex, e.g., TSC2,RPTOR for the crosstalk from the MAPK signaling pathway to the mTOR signaling pathway (both TSC2 and RPTOR act as mediators).
  • brackets ([]): If we cannot identify the specific molecule, we record all molecules in the family, e.g., [TEAD1/TEAD2/TEAD3/TEAD4]. In this case, the publication only listed the protein TEAD as mediating the crosstalk (from the Hippo signaling pathway to the Wnt signaling pathway).